Vetoryl

Vetoryl (Trilostane) is a veterinary drug indicated for the treatment of hyperadrenocorticism or Cushing`s syndrome, a commonly diagnosed endocrine disorder in dogs, especially older ones. This condition can cause skin diseases, alopecia, lethargy, polyuria, muscular weakness as well as other symptoms. This occurs due to excess amounts of glucocorticoids such as cortisol (a hormone that the adrenal glands produce).

Cushing`s syndrome may be caused by a benign tumor in the pituitary gland (pituitary dependant hyperadrenocorticism, the most common form of the disease, affecting 80% of animals diagnosed with hyperadrenocorticism ) or else adrenal dependent hyperadrenocorticism, which is less common and is caused by a tumor in either one or both of the adrenal glands. Treatment with this medicine aims to manage the symptoms, by causing a significant reduction in the serum cortisol concentrations, which in turn may help to reverse the clinical signs of Cushing`s syndrome. However, it will not cure the condition.

In addition to a physical examination, blood tests will be required before treatment with Vetoryl (Trilostane) can begin, so that the veterinarian can confirm that the dog`s symptoms are caused by Cushing`s syndrome. Other tests may be needed so as to find out whether it is a pituitary or adrenal gland tumor that is causing the symptoms. The veterinarian will calculate an appropriate dosage based on the weight of the dog and the size of the capsule, and in some cases, vets have prescribed a starting dose ranging from 1mg to 3mg per pound per day. Regular visits to the veterinarian`s clinic will be needed, so that the dog`s response to treatment can be monitored and the dosage adjusted if necessary.

If side effects occur during treatment with Vetoryl (Trilostane), veterinary care may be needed. Some examples of possible reactions are provided here:

• Vomiting
• Loose stools
• Poor appetite
• Lethargy
• Low levels of energy

Your dog should be brought to a vet immediately if any side effects occur.

This drug is only indicated and approved for the treatment of animals. It must not be taken by humans under any circumstances.

Prior to the commencement of treatment, the veterinarian may screen your dog for renal insufficiency and hepatic disease, as this medicine may not be suitable for animals with these conditions.