Zoladex LA

Zoladex LA Implant (Goserelin)  is an anti-cancer medication prescribed for the treatment of prostate cancer.

It has medicinal form of implant in pre-filled syringes. 1 implant contains goserelin acetate 12,50 mg in terms of goserelin 10,8 mg.

Zoladex LA Implant (Goserelin) is a synthetic analogue of the natural luteinizing hormone - releasing hormone (LHRH). With the constant use of goserelin 10.8 mg, it inhibits the secretion of the luteinizing hormone by the pituitary gland, leading to a lower serum testosterone concentration in men and estradiol in women. At the initial stage, goserelin 10.8 mg, like other LHRH agonists, may cause a temporary increase in serum testosterone concentrations in men and estradiol in women.

Approximately on the 21st day after the first injection, testosterone concentration in men falls to the level of castration and remains low with continued use of the drug every 28 days.

Inhibition of the production of testosterone leads to regression of prostate tumors and symptomatic improvement in most patients.

In a combined analysis of two randomized controlled trials comparing monotherapy with biculamate 159 mg and castration (mainly in the form of goserelin), no significant difference was observed in the overall survival rate in patients with prostate cancer receiving bicalutamide and in patients were treated in the form of castration (relative risk = 1.05 [SI 0.81 to 1.36]). However, the equivalence of two methods of treatment can not be estimated statistically.

Always follow your doctor`s instructions when using Zoladex LA Implant (Goserelin) to get the safest and most effective results from treatment. The typical dosage is 1 injection every 28 days. Zoladex LA Implant (Goserelin) should be carefully administered to the anterior abdominal wall due to the proximity of the lower abdominal artery and its branches.

Particular care should be taken when using Zoladex LA Implant (Goserelin) for patients with low BMI and / or those who receive drugs for complete anticoagulation.

Care must be taken to ensure that the injection is performed subcutaneously. Do not inject the needle into the blood vessel, muscle or abdominal cavity.

Local anesthetic is permitted, but in most cases it is not needed.

Always ask your doctor any questions you have about using the medication to ensure the correct administration.

The use of Zoladex LA Implant (Goserelin) may cause side effects in some patients including:

• Decrease libido
• Mood changes, depression
• Paresthesia
• Hyperhidrosis
• Redness
• Erectile dysfunction
• Gynecomastia
• Increase in body weight

Contact your doctor immediately if you experience any serious or worrying symptoms!

Zoladex LA Implant (Goserelin) should not be used by patients who are breastfeeding, under the age of eighteen, or hypersensitivity to goserelin acetate or to other analogues of LHRH (luteinizing hormone - releasing hormone).

Strictly use Zoladex LA Implant (Goserelin) as prescribed and follow all instructions provided by your doctor. Safe, suitable, and optimum dosage can vary and is dependent on the patient`s health and medical history, as well as the condition you are treating.

Zoladex LA Implant (Goserelin)may not be safe or suitable for all patients. Always ensure your doctor is informed if you are pregnant or breastfeeding, using any other type of medication (including non-prescription medicine, vitamins, and supplements), as well as if you have any allergies, other illnesses, or pre-existing medication conditions.

Seek immediate medical attention or proceed to your nearest accident and emergency department if you suffer a hypersensitive or allergic reaction.